magazineAuthors: Dang Mai Lien; Le Thi Hong Hanh; Trinh Thi Dung (2020)
Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disease which is
one kind of the phagocytic dysfunction. It is accounted for 1 : 200000 live births in the United States. The
mechanism of CGD is mutation in any structural molecules of Nicotinamid Adenine Dinucleotide Phosphate
(NADPH) oxidase. Therefore, CGD increases the body’s susceptibility to infections caused by bacteria and
fungi with granulomas formed at the sites of infection or inflammation. We report 4 cases diagnosed as
suspected CGD in patients suffering from persistent pneumonia in the respiratory unit in Vietnam National
Children’s Hospital to recommend colleagues not to mis-diagnose CGD... 
