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  • Acute and subchronic oral toxicity assessments of BTL tea in experimental animals

    • Authors: Tran Thai Ha, Bui Viet Chung (2021)

  • Tobacco smoking remains a leading cause of preventable diseases and premature death in many countries. Many smokers want to quit smoking but are not offered the highly effective treatments available to manage tobacco dependency. There has been a current trend for researchers to find new natural ingredients that were safe and still effective in treating tobacco dependence. BTL tea was a herbal-derived product prepared from Herba Menthae, Pogos cablin (Blanco) Benth., Zingiber Officinale Rosc.,
  • Article

  • Subchronic oral toxicity of rabella powder in experimental rats

    • Authors: Pham Thi Van Anh, Tran Thai Ha; Ta Minh Nguyet (2021)

  • It has recently become obvious that the prevalence of obesity has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which are safe and effective in the treatment of obesity. RABELLA powder was a herbal-derived product which contained Amorphophalus konjac (K. Koch starch).
  • Article

  • The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals

    • Authors: Pham Thi Van Anh, Nguyen Van Dam (2021)

  • The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and ...