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  • Toxicity evaluation of acute and sub-chronic oral toxicity of Hamo NK hard capsule in experimental animals

    • Authors: Dang Thi Thu Hien; Nguyen Trong Thong; Pham Thuy Phuong (2020)

  • Hamo NK hard capsule is composed of dry extracts formulation of herbal medicine which had shown good properties for effective treatment of dyslipidemia. However, there are no scientific report of its toxicological properties which would guarantee its safe usage as a potent treatment of dyslipidemia. Therefore, the present study was to investigate acute and sub-chronic toxicity of Hamo NK on mice and rats through oral administration. Acute toxicity study was performed in Swiss mice at tolerable ascending doses in mice and followed up to 7 days
  • Article

  • Acute and sub-chronic oral toxicities of DA.Amlodepon HVD hard capsule in experimental animals

    • Authors: Pham Thi Van Anh, Nguyen Van Dam; Nguyen Van Dat (2021)

  • Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated. Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and fourth week (T2).