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  • Evaluation of acute and subchronic toxicity of TD0019 hard capsules in experimental animals

    • Authors: Trinh Thi Lua (2019)

  • TD0019 hard capsules were prepared from the traditional remedy called “duhuojisheng decoction” and integrated dry extract from the bark of Eucalyptus exserta F.v Muell with fermented Glycine Max (L) Merr. Extract. These components have a potential analgesic, acute and chronic anti - inflammatory effects on experimental animals
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  • The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals

    • Authors: Pham Thi Van Anh, Nguyen Van Dam (2021)

  • The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and ...