ArticleTác giả : Pham Thi Van Anh, Nguyen Van Dam (2021)
The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD
capsules through oral administration in experimental animals. The acute toxicity was determined by the method
of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO
and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/
day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD
capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term
of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters,
hepato-renal functions, macroscopic and ... 
