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  • Article

  • A case of primary breast diffuse large B cell lymphoma

    • Authors: Trinh Le Huy, Tran Dinh Anh (2021)

  • Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin’s lymphoma with limited data. We here report a case of primary breast diffuse large B-cell lymphoma mimicking breast cancer. A 52-year old woman had a painless mass in her right breast. Fine needle aspiration cytology and core biopsy were performed which suggested malignant features but could not confirm the specific subtype. Excisional biopsy then was conducted revealing non-Hodgkin lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5cm sized breast mass with skin thickening and modest lymphadenopathy in the ipsilateral axilla. The patient received six courses of R-CHOP (cyclophospham...
  • Article

  • Evaluating the result of sphincteric-preserving surgery (parks procedure) for low rectal cancer

    • Authors: Trinh Le Huy, Ngo Van Ty (2021)

  • Sphincter-preserving surgery for low rectal cancer improved the quality of life while maintaining the oncologic outcomes. A retrospective, descriptive study was conducted with 45 patients who underwent sphincter-preserving surgery for low rectal cancer at the National Cancer Hospital and Hanoi Medical University Hospital between January 2016 and April 2020. The mean age was 55.6 years old. Male: female ratio = 0.7:1. Nearly all patients presented with hematochezia (95.6%). 75.6% of the tumors are located within 4-6 cm from the anal verge. The anastomotic leak rate was 4.4%. All patients had a normal postoperative urinary function. The sexual dysfunction rate was low (15.8%) and reversible. None had erectile or ejaculation dysfunction. 97.8% satisfied with sphincter fun...
  • Article

  • St-elevation myocardial infraction complicated by cardiac arrest in a young patient with familial dyslipidemia

    • Authors: Pham Minh Tuan, Doan Tuan Vu (2021)

  • Coronary heart disease in young patients always poses great challenges for every healthcare system with differences in clinical manifestations, etiology, epidemiology, angiographic characteristics and prognosis. The objective of this study was to describe a case of ST-elevation myocardial infarction complicated by cardiac arrest in a young patient with familial dyslipidemia. A 30-year-old male visited our hospital with typical angina. During the examination, he suffered a sudden loss of consciousness, the monitor showed ventricular fibrillation. After successful resuscitation of cardiac arrest, electrocardiography showed apparent ST-elevation from V2 to V6 leads consistent with the diagnosis of anterolateral infarction
  • Article

  • Prevalence and related factors of alcohol consumption among ethnic minority boarding high schoolers in southern Vietnam

    • Authors: Nguyen Thanh Binh, Le Thi Diem Trinh; Pham Duy Quang (2021)

  • Hazardous levels of alcohol use have caused many diseases, posing a great economic and social burden to the community. Alcohol use in some provinces of Vietnam shows that alcohol consumers are getting younger and younger. This study aimed to determine the proportion of alcohol consumption among students at Binh Phuoc Ethnic Minority High School in 2020 and a number of factors leading to the alcohol consumption. The result showed that the alcohol use proportion in the past 12 months was 62% and the risky drinkers rate was 11.2%. Some factors concerning the use of alcohol among students such as gender, age, grade level, behavior, smoking, alcohol use family members, alcoholic friends, and friends influence were also revealed in the study
  • Article

  • The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals

    • Authors: Pham Thi Van Anh, Nguyen Van Dam (2021)

  • The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and ...
  • Article

  • Sub-chronic oral toxicity study of "Kien Nao Dan" tablets in experimental animal

    • Authors: Le Thanh Xuan, Le Thi Nhat Ngoc (2021)

  • The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. The histopathology analysis of livers and kidneys indicated that no significant difference was obs...
  • Article

  • Sub-chronic oral toxicity study of "Phong Thap Dan" tablets in experimental animal

    • Authors: Trinh Thi Thuy Hong, Le Thanh Xuan; Tran Quang Minh (2021)

  • “Kien nao dan” (KND) tablet is composed of 13 traditional medicines that may has preventive and effective treatment of cerebral ischemia. However, there are no scientific reports of its toxicological properties which guarantee of the safety its usage treatment. Therefore, the aim of this study was to investigate the sub-chronic toxicity of KND tablet on rats through oral administration. The sub-chronic toxicity was evaluated by the recommendation of WHO in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological changes or signs of toxicity. The result of the hematological and biologi...
  • Article

  • Nutritional status of patients undergoing upper gastrointestinal cancer surgery: a cross-sectional study at a single centre

    • Authors: Tran Hieu Hoc, Nguyen Duy Hieu; Pham Van Phu (2021)

  • Malnutrition is closely related to the outcome of disease treatment, especially in digestive cancer surgery. The aim of this study was to assess the nutritional condition of pre-operative patients with upper digestive cancers (including stomach and oesophagus) at the Department of General Surgery, Bach Mai Hospital in 2016. We conducted a cross-sectional descriptive analysis of 76 malignancies of the upper gastrointestinal tract with surgical treatments
  • Article

  • Cerebral venous sinus thrombosis relate to vaccine-induced immune thrombotic thrombocytopenia: first reported case in Viet Nam

    • Authors: Hoang Bui Hai, Do Giang Phuc; Nguyen Thanh Chung (2021)

  • Vaccination remains one of the most important public health interventions to control and mitigate the impacts of COVID-19 worldwide. A number of post-vaccination reactions have caused concern and are the cause of vaccine hesitancy. Vaccine-induced immune thrombotic thrombopenia (VITT) has been reported in several countries such as Norway at a rate of 1 per 26000 doses of the ChAdOx1 nCoV vaccine (AstraZeneca), 15 per 8 million doses of Ad26.COV2.S (Janssen; Johnson & Johnson) vaccines in the US. In Vietnam, 11.5 million doses of AstraZeneca vaccine have been administered since the commencement of a nation wide vaccination program five months ago. We report the first case of cerebral venous thrombosis related to VITT which was promptly diagnosed and successfully treated w...