ArticleAuthors: Le Thanh Xuan, Le Thi Nhat Ngoc (2021)
The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets
through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO
recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16
g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD
was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were
no behavioral and physiological change or sign of toxicity. The result of the hematological and biological
parameters after administration of PTD tablets showed no change. The histopathology analysis of livers
and kidneys indicated that no significant difference was obs...