Analgesic activity of Phong Thap Dan tablets in animal models

Abstract

Phong thap dan tablets are intended to treat low back pain. This study was carried out to evaluate the analgesic effects of Phong thap dan tablets in experimental animals. The analgesic effects were evaluated in three animal models: hot plate, mechanical stimulation and acetic acid-induced writhing test. Mice were divided into 4 groups given oral water, control drug (codein phosphate in hot plate and mechanical stimulation tests or aspirin in writhing test), Phong thap dan at 2.88 tablets (1.44 g) or 8.64 tablets (4.32 g)/kg b.w/day, respectively. Our results showed that Phong thap dan tablets at both doses increased the reaction time to thermal stimulation, increased the paw withdrawal latency and the force required to elicit a paw withdrawal and decreased the number of acetic acid-induced writhing movements in mice. There was no statistically significant difference between 2 doses of Phong thap dan tablets in three animal models. We conclude that Phong thap dan tablets at the doses of 2.88 tablets and 8.64 tablets/kg b.w/day showed significant analgesic effect in animal models