4 cases from suspected chronic granulomatous disease in the respiratory unit in Vietnam national children's hospital

Abstract

Chronic granulomatous disease (CGD) is an inherited primary immunodeficiency disease which is one kind of the phagocytic dysfunction. It is accounted for 1 : 200000 live births in the United States. The mechanism of CGD is mutation in any structural molecules of Nicotinamid Adenine Dinucleotide Phosphate (NADPH) oxidase. Therefore, CGD increases the body’s susceptibility to infections caused by bacteria and fungi with granulomas formed at the sites of infection or inflammation. We report 4 cases diagnosed as suspected CGD in patients suffering from persistent pneumonia in the respiratory unit in Vietnam National Children’s Hospital to recommend colleagues not to mis-diagnose CGD in recurrent or persistent pneumonia.