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  • Article

  • Sub-chronic oral toxicity study of "Phong Thap Dan" tablets in experimental animal

    • Authors: Trinh Thi Thuy Hong, Le Thanh Xuan; Tran Quang Minh (2021)

  • “Kien nao dan” (KND) tablet is composed of 13 traditional medicines that may has preventive and effective treatment of cerebral ischemia. However, there are no scientific reports of its toxicological properties which guarantee of the safety its usage treatment. Therefore, the aim of this study was to investigate the sub-chronic toxicity of KND tablet on rats through oral administration. The sub-chronic toxicity was evaluated by the recommendation of WHO in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose) for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological changes or signs of toxicity. The result of the hematological and biologi...
  • Article

  • Nutritional status of patients undergoing upper gastrointestinal cancer surgery: a cross-sectional study at a single centre

    • Authors: Tran Hieu Hoc, Nguyen Duy Hieu; Pham Van Phu (2021)

  • Malnutrition is closely related to the outcome of disease treatment, especially in digestive cancer surgery. The aim of this study was to assess the nutritional condition of pre-operative patients with upper digestive cancers (including stomach and oesophagus) at the Department of General Surgery, Bach Mai Hospital in 2016. We conducted a cross-sectional descriptive analysis of 76 malignancies of the upper gastrointestinal tract with surgical treatments
  • Article

  • Cerebral venous sinus thrombosis relate to vaccine-induced immune thrombotic thrombocytopenia: first reported case in Viet Nam

    • Authors: Hoang Bui Hai, Do Giang Phuc; Nguyen Thanh Chung (2021)

  • Vaccination remains one of the most important public health interventions to control and mitigate the impacts of COVID-19 worldwide. A number of post-vaccination reactions have caused concern and are the cause of vaccine hesitancy. Vaccine-induced immune thrombotic thrombopenia (VITT) has been reported in several countries such as Norway at a rate of 1 per 26000 doses of the ChAdOx1 nCoV vaccine (AstraZeneca), 15 per 8 million doses of Ad26.COV2.S (Janssen; Johnson & Johnson) vaccines in the US. In Vietnam, 11.5 million doses of AstraZeneca vaccine have been administered since the commencement of a nation wide vaccination program five months ago. We report the first case of cerebral venous thrombosis related to VITT which was promptly diagnosed and successfully treated w...
  • Article

  • A case report of refractory congenital chylous ascites in infant - surgical treatment with fibrin glue

    • Authors: Nguyen Van Tinh, Nguyen Thi Viet Ha (2021)

  • Congenital chylous ascites is a rare disease that results from abnormal development of the intra-abdominal lymphatic system. No gold standard treatment has been described so far, however, a combination of medium–chain triglyceride based diet or total parenteral nutrition along with octreotide and abdominal paracentesis is considered as a conservative management. This treatment is often a challenge to physicians since chylous ascites is often refractory and result in malnutrition and immune deficiency because of the loss of proteins and lymphocytes. We report a four-month old boy with congenital chylous ascites who was refractory to medical treatment with prolonged bowel rest, total parenteral nutrition, octreotide and repeated paracentesis. The baby well responded to sur...
  • Article

  • Analgesic activity of Phong Thap Dan tablets in animal models

    • Authors: Le Thi Nhat Ngoc, Le Thanh Xuan (2021)

  • Phong thap dan tablets are intended to treat low back pain. This study was carried out to evaluate the analgesic effects of Phong thap dan tablets in experimental animals. The analgesic effects were evaluated in three animal models: hot plate, mechanical stimulation and acetic acid-induced writhing test. Mice were divided into 4 groups given oral water, control drug (codein phosphate in hot plate and mechanical stimulation tests or aspirin in writhing test), Phong thap dan at 2.88 tablets (1.44 g) or 8.64 tablets (4.32 g)/kg b.w/day, respectively. Our results showed that Phong thap dan tablets at both doses increased the reaction time to thermal stimulation, increased the paw withdrawal latency and the force required to elicit a paw withdrawal and decreased the number ...