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    Browsing by Subject acute toxicity

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    • Article

    • Acute and sub-chronic oral toxicities of DA.Amlodepon HVD hard capsule in experimental animals

      • Authors: Pham Thi Van Anh, Nguyen Van Dam; Nguyen Van Dat (2021)

    • Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated. Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and fourth week (T2).
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    • Article

    • Acute and subchronic oral toxicity assessments of BTL tea in experimental animals

      • Authors: Tran Thai Ha, Bui Viet Chung (2021)

    • Tobacco smoking remains a leading cause of preventable diseases and premature death in many countries. Many smokers want to quit smoking but are not offered the highly effective treatments available to manage tobacco dependency. There has been a current trend for researchers to find new natural ingredients that were safe and still effective in treating tobacco dependence. BTL tea was a herbal-derived product prepared from Herba Menthae, Pogos cablin (Blanco) Benth., Zingiber Officinale Rosc.,
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    • Article

    • Evaluation of acute and subchronic toxicity of "Tran Chau Nguu Hoang Hoan" in experimental animals

      • Authors: Tran Thai Ha, Pham Thi Van Anh; Dao Xuan Tinh (2021)

    • “Tran chau nguu hoang hoan” was prepared from 12 herbal ingredients. So far, the safety of this product, has not been reported yet. Thus, this study aimed to evaluate the acute and subchronic toxicity of “Tran chau nguu hoang hoan” through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in mice at the doses of 2.42 g/kg b.w/day to 6.04 g/kg b.w/day. The subchronic toxicity was evaluated followed the Guideline of WHO and OECD in rats with oral doses of 58.0 mg/kg b.w/day and 174.0 mg/kg b.w/day for 12 consecutive weeks. As a result, in the course of the acute toxicity test, the mice showed no abnormal sign ...
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    • Article

    • Evaluation of acute and subchronic toxicity of TD0019 hard capsules in experimental animals

      • Authors: Trinh Thi Lua (2019)

    • TD0019 hard capsules were prepared from the traditional remedy called “duhuojisheng decoction” and integrated dry extract from the bark of Eucalyptus exserta F.v Muell with fermented Glycine Max (L) Merr. Extract. These components have a potential analgesic, acute and chronic anti - inflammatory effects on experimental animals
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    • Article

    • The evaluation of acute and subchronic toxicities of an Phu Khang capsules in experimental animals

      • Authors: Ha Thi Yen, Tran Thanh Tung (2021)

    • The purpose of this research was to evaluate the acute and subchronic toxicities of An Phu Khang capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO in Wistar rats at these doses of 0.54 g/kg b.w/day (equal to recommended human dose) and 1.62 g/kg b.w/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result
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    • Article

    • The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals

      • Authors: Pham Thi Van Anh, Nguyen Van Dam (2021)

    • The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG H...
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    • magazine

    • Toxicity evaluation of acute and sub-chronic oral toxicity of Hamo NK hard capsule in experimental animals

      • Authors: Dang Thi Thu Hien; Nguyen Trong Thong; Pham Thuy Phuong (2020)

    • Hamo NK hard capsule is composed of dry extracts formulation of herbal medicine which had shown good properties for effective treatment of dyslipidemia. However, there are no scientific report of its toxicological properties which would guarantee its safe usage as a potent treatment of dyslipidemia. Therefore, the present study was to investigate acute and sub-chronic toxicity of Hamo NK on mice and rats through oral administration. Acute toxicity study was performed in Swiss mice at tolerable ascending doses in mice and followed up to 7 days