ArticleAuthors: Trinh Thi Thuy Hong, Le Thanh Xuan; Tran Quang Minh (2021)
“Kien nao dan” (KND) tablet is composed of 13 traditional medicines that may has preventive and effective
treatment of cerebral ischemia. However, there are no scientific reports of its toxicological properties which
guarantee of the safety its usage treatment. Therefore, the aim of this study was to investigate the sub-chronic
toxicity of KND tablet on rats through oral administration. The sub-chronic toxicity was evaluated by the
recommendation of WHO in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16
g/kg/day (3 times as high as recommended human dose) for 8 consecutive weeks. In the evaluation of sub-chronic
toxicity, there were no beha... 
