ArticleAuthors: Pham Thi Van Anh, Nguyen Van Dam; Nguyen Van Dat (2021)
Assessment of toxicities of DA.AMLODEPON HVD hard capsule on experimental animals. The acute
toxicity of DA.AMLODEPON HVD was assessed on Swiss mice according to World Health Organization
Guidance, and LD50 determination according to the method of Litchfield – Wilcoxon. The sub-chronic toxicity
study of DA.AMLODEPON HVD at two doses (0.42 g/kg/day and 1.26g/kg/day) was conducted in rats for
four consecutive weeks. After administration, general conditions and the body weight of rats were evaluated.
Blood samples were collected for analyzing serum parameters before treatment (T0), second week (T1), and
fourth week (T2). 
