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    Browsing by Author Le Thanh Xuan, Le Thi Nhat Ngoc

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    • Article

    • Sub-chronic oral toxicity study of "Kien Nao Dan" tablets in experimental animal

      • Authors: Le Thanh Xuan, Le Thi Nhat Ngoc (2021)

    • The present study aimed to investigate the sub-chronic toxicity of “Phong thap dan” (PTD) tablets through oral administration in experimental animal. The sub-chronic toxicity was evaluated by the WHO recommendation in Wistar rats at doses of 0.72 g/kg/day (equal to recommended human dose) and 2.16 g/kg/day (3 times as high as recommended human dose). In the sub-chronic experimental group, the PTD was administered orally daily for 8 consecutive weeks. In the evaluation of sub-chronic toxicity, there were no behavioral and physiological change or sign of toxicity. The result of the hematological and biological parameters after administration of PTD tablets showed no change. ...