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  • magazine

  • A subchronic toxicity study of RA liquid extract in experimental animals

    • Authors: Nguyen Ngoc Trung (2020)

  • Arachis hypogaea L. extract is the main ingredient of RA liquid extract, a product of Military Institute of Traditional Medicine. So far, the safety of RA liquid extract has not been reported yet. Thus, this study aimed to investigatethe subchronic oral toxicity of RA at doses of 14 g/kg b.w/day and 42 g/ kg b.w/day in rats within 90 consecutive days following the recommendation of WHO and OECD
  • Article

  • Evaluation of acute and subchronic toxicity of TD0019 hard capsules in experimental animals

    • Authors: Trinh Thi Lua (2019)

  • TD0019 hard capsules were prepared from the traditional remedy called “duhuojisheng decoction” and integrated dry extract from the bark of Eucalyptus exserta F.v Muell with fermented Glycine Max (L) Merr. Extract. These components have a potential analgesic, acute and chronic anti - inflammatory effects on experimental animals
  • magazine

  • Subchronic toxicity evaluation of diatarin in experimental animals

    • Authors: Dinh Thi Thu Hang; Pham Thi Van Anh; Vong Binh Long (2020)

  • Diatarin was a product of the Ipharm Vietnam Pharmaceutical Joint Stock Company. So far, the safety of Diatarin has not been reported yet. Thus, this study was to investigate the subchronic oral toxicity of Diatarin at doses of 163.2 mg/kg b.w/day and 489.6 mg/kg b.w/day in rats during consecutive 12 weeks following the recommendation of WHO and OECD
  • magazine

  • Acute and subchronic oral toxicities of "Da day An Chau" tablets in experimental animals

    • Authors: Tran Thanh Tung; Dao Viet Hoang; Pham Thi Van Anh; Dang Thi Thu Hien (2020)

  • In this study, the toxicities of “Da day An Chau” tablets (DDAC) were assessed on experimental animals. To evaluate the acute toxicity on Swiss mice according to World Health Organization Guidance and to determine LD50 refer to the method of Litchfield – Wilcoxon.
  • Article

  • Acute and subchronic oral toxicity assessments of BTL tea in experimental animals

    • Authors: Tran Thai Ha, Bui Viet Chung (2021)

  • Tobacco smoking remains a leading cause of preventable diseases and premature death in many countries. Many smokers want to quit smoking but are not offered the highly effective treatments available to manage tobacco dependency. There has been a current trend for researchers to find new natural ingredients that were safe and still effective in treating tobacco dependence. BTL tea was a herbal-derived product prepared from Herba Menthae, Pogos cablin (Blanco) Benth., Zingiber Officinale Rosc.,
  • Article

  • Subchronic oral toxicity of rabella powder in experimental rats

    • Authors: Pham Thi Van Anh, Tran Thai Ha; Ta Minh Nguyet (2021)

  • It has recently become obvious that the prevalence of obesity has been rapidly increasing in Vietnam, as well as other countries, over the past two decades. There has been a current trend for researchers to discover new natural ingredients which are safe and effective in the treatment of obesity. RABELLA powder was a herbal-derived product which contained Amorphophalus konjac (K. Koch starch).
  • Article

  • The study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals

    • Authors: Pham Thi Van Anh, Nguyen Van Dam (2021)

  • The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/ day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and ...